A case of intrahepatic cholestasis due to D-penicillamine
نویسندگان
چکیده
منابع مشابه
Cholestasis due to D-penicillamine toxicity.
A patient with sero-positive rheumatoid arthritis was treated with D-penicillamine (cumulative dose 3 . 7 3 9 . Three weeks after starting therapy she developed a fever, rash and a cholestatic jaundice. Cessation of D-penicillamine resulted in improvement. However, reintroduction of D-penicillamine 1 0 days later (cumulative dose 2g), was followed by acute hepatic failure and death. Liver biops...
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Two West Indian patients with Kveim-biopsy proven sarcoidosis developed chronic cholestatic liver disease, clinically and biochemically similar to primary biliary cirrhosis. Liver histology revealed multiple granulomas with reduction in bile ducts and, in one patient, progression to biliary cirrhosis. Portal hypertension was present in both patients leading to severe variceal haemorrhage in one...
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Introduction Progressive familial intrahepatic cholestasis (PFIC) represents a group of disorders which usually begin in the first months of life and progress to cirrhosis before the end of second decade. The disease occurs due to a defect in bile acid transport leading to cholestasis and resultant hepatocelluler injury1-3. Recent molecular and genetic studies have identified genes responsible ...
متن کاملExchange transfusion for intrahepatic cholestasis due to sickle beta thalassaemia.
Intrahepatic cholestasis is a rare but potentially fatal complication of sickle cell disease [1]. Sickle cell intrahepatic cholestasis (SCIC) is characterised by right upper quadrant pain, hepatomegaly and progressive hyperbilirubinaemia. To date 15 adult patients have been reported in the literature and only six survived [2]. We present a case of haemoglobin S/Beta thalassaemia with intrahepat...
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This paper reports the case of a child in which the clinical and laboratory data indicate a progressive intrahepatic cholestasis of the type described as Byler's disease. The histological and histochemical findings suggest an intrahepatic cholestasis. Electron microscopy reveals interruptions of the bile canalicular membrane, which have been described as characteristic of this disease. A stri...
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ژورنال
عنوان ژورنال: Kanzo
سال: 1979
ISSN: 0451-4203,1881-3593
DOI: 10.2957/kanzo.20.616